Roche Rolls Out New DNA ‘Sequencing-by-Expansion’ Approach

Roche has put forward a new approach to genetic analysis, which it describes as sequencing-by-expansion—a proprietary method that pulls apart the DNA molecule and amplifies the signal of each individual base. The company said its technique—which combines aspects of DNA synthesis and nanopore-based molecule reading—can avoid the time requirements of cycle-based sequencing as well as the comparable difficulties in distinguishing true signals among the noise.