Breyanzi, a CD19-directed CAR T cell therapy, is approved for patients with relapsed or refractory chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) who have already received treatment with a Bruton tyrosine kinase inhibitor (BTKi) and B cell lymphoma 2 inhibitor (BCL2i).
BTKi and BCL2i therapies are the most common and most effective treatment options for CLL, said David Porter, director of Cell Therapy and Transplantation at Penn Medicine’s Abramson Cancer Center. “When patients have failed both of those, the prognosis is terrible,” he told BioSpace. “They have truly very few effective treatment options at that point. This will offer one of the best, most potent, effective options for patients who have failed the more conventional therapy.”