Institute for Systems Biology’s Computational Models Forecast C. diff Infections Before They Develop

Scientists at the Institute for Systems Biology have created a personalized modeling framework to predict an individual’s risk of gut colonization by Clostridioides difficile (C. diff) and evaluate potential prebiotic therapies for prevention or treatment. Detailed in Cell Systems, the tool addresses a major healthcare threat that infects over 500,000 Americans annually, offering insights into why some carriers develop infections while others remain healthy.